100758-63-2Relevant academic research and scientific papers
Chemical characteristic of an anticoagulant-active sulfated polysaccharide from Enteromorpha clathrata
Qi, Xiaohui,Mao, Wenjun,Gao, Yan,Chen, Yin,Chen, Yanli,Zhao, Chunqi,Li, Na,Wang, Chunyan,Yan, Mengxia,Lin, Cong,Shan, Jimiao
, p. 1804 - 1810 (2012/11/13)
A sulfated polysaccharide FEP from marine green alga Enteromorpha clathrata was extracted with hot water and further purified by ion-exchange and size-exclusion chromatography. Results of chemical and spectroscopic analyses showed that FEP was a high arabinose-containing sulfated polysaccharide with sulfate ester of 31.0%, and its average molecular weight was about 511 kDa. The backbone of FEP was mainly composed of (1 → 4)-linked β-l- arabinopyranose residues with partially sulfate groups at the C-3 position. In vitro anticoagulant assay indicated that FEP effectively prolonged the activated partial thromboplastin time and thrombin time. The investigation demonstrated that FEP was a novel sulfated polysaccharide with different chemical characteristics from other sulfated polysaccharides from marine algae, and could be a potential source of anticoagulant.
