1007586-73-3Relevant academic research and scientific papers
Diazo Activation with Diazonium Salts: Synthesis of Indazole and 1,2,4-Triazole
Li, Xuming,Ye, Xiaohan,Wei, Chiyu,Shan, Chuan,Wojtas, Lukasz,Wang, Qilin,Shi, Xiaodong
supporting information, p. 4151 - 4155 (2020/06/05)
A donor/acceptor diazo activation strategy, processing via condensation using diazonium salts without the addition of any other catalysts or reagents, is reported. The diazenium intermediate was found to undergo cyclization to give indazoles in excellent yields. Alternatively, in the presence of nitriles, substituted 1,2,4-triazoles were obtained in good to excellent yields. This interesting diazenium route provides a new approach to achieve complex heterocycle synthesis under mild conditions.
Asymmetric Synthesis of a 5,7-Fused Ring System Enabled by an Intramolecular Buchner Reaction with Chiral Rhodium Catalyst
Hoshi, Takayuki,Ota, Eisuke,Inokuma, Yasuhide,Yamaguchi, Junichiro
, p. 10081 - 10084 (2019/12/27)
A Rh-catalyzed asymmetric intramolecular Buchner ring expansion of α-alkyl-α-diazoesters has been developed. The present protocol generates a 5,7-fused ring system in an enantioselective manner while minimizing β-hydrogen migration, which has been a competing reaction when using α-alkyl-α-diazoesters. The ester functionality at the bridgehead position would be a useful synthetic handle for further derivatization to complex molecules including natural products.
Palladium-catalyzed cross-coupling of α-diazocarbonyl compounds with arylboronic acids
Peng, Cheng,Wang, Yan,Wang, Jianbo
, p. 1566 - 1567 (2008/09/17)
Pd(PPh3)4-catalyzed reaction between α-diazocarbonyl compounds and arylboronic acids leads to the formation of cross-coupling products in good yields. Copyright
