1007587-64-5Relevant academic research and scientific papers
Encoded dendrimers with defined chiral composition via 'click' reaction of enantiopure building blocks
Yeniad, Bahar,Naik, Hemantkumar,Amir, Roey J.,Koning, Cor E.,Hawker, Craig J.,Heise, Andreas
, p. 9870 - 9872 (2011)
Dendrimers with end-groups of defined chiral composition have been prepared from alkyne functional enantio-pure building blocks obtained by selective enzymatic (ADH) ketone reductions using click chemistry. Optical rotation and enantioselective enzymatic
ANTIBACTERIAL AND ANTIFUNGAL PLEUROMUTILIN CONJUGATES
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Page/Page column 40, (2021/11/06)
Compounds of formula (1) comprising a pleuromutilin backbone with a triazole based side-group at C22 are provided. The compounds can be used for treatment of bacterial infections and fungal infections. Importantly, infections caused by multidrug-resistant
Investigation of asymmetric alcohol dehydrogenase (ADH) reduction of acetophenone derivatives: Effect of charge density
Naik, Hemantkumar G.,Yeniad, Bahar,Koning, Cor E.,Heise, Andreas
supporting information; experimental part, p. 4961 - 4967 (2012/08/08)
In an effort to study the effect of substituent groups of the substrate on the alcohol dehydrogenase (ADH) reductions of aryl-alkyl ketones, several derivatives of acetophenone have been evaluated against ADHs from Lactobacillus brevis (LB) and Thermoanaerobacter sp. (T). Interestingly, ketones with non-demanding (neutral) para-substituents were reduced to secondary alcohols by these enzymes in enantiomerically pure form whereas those with demanding (ionizable) substituents could not be reduced. The effect of substrate size, their solubility in the reaction medium, electron donating and withdrawing properties of the ligand and also the electronic charge density distribution on the substrate molecules have been studied and discussed in detail. From the results, it is observed that the electronic charge distribution in the substrate molecules is influencing the orientation of the substrate in the active site of the enzyme and hence the ability to reduce the substrate.
Click-connected ligand scaffolds: macrocyclic chelates for asymmetric hydrogenation
Qing, Zhang,Takacs, James M.
, p. 545 - 548 (2008/09/17)
Click chemistry is used to construct ligand scaffolds for a series of chiral diphosphites. Enantioselectivity as high as 97% ee is obtained using these click ligands in rhodium-catalyzed asymmetric hydrogenation. Control experiments and spectroscopic data suggest that a 16-membered P,P-macrocyclic Rh(1) chelate is formed.
