1007597-69-4Relevant academic research and scientific papers
Irregularities in the effect of potassium phosphate in ynamide synthesis
Dooleweerdt, Karin,Birkedal, Henrik,Ruhland, Thomas,Skrydstrup, Troels
supporting information; experimental part, p. 9447 - 9450 (2009/04/06)
(Chemical Equation Presented) The yields of ynamides using Hsung's second generation protocol depend substantially on the quality of K3PO 4. Samples of K3PO4 from different suppliers were investigated by various techniques, revealing that the use of pure and anhydrous K3PO4 provides higher ynamide yields in comparison to samples contaminated with hydrates (K3PO 4·1.5H2O and K3PO4· 7H2O). With high quality K3PO4, a number of ynamides were synthesized in yields of 52-91%. In addition, we report that ynamides can undergo regioselective hydroamination with carbamates.
Copper-catalyzed aerobic oxidative amidation of terminal alkynes: Efficient synthesis of ynamides
Hamada, Tetsuya,Ye, Xuan,Stahl, Shannon S.
, p. 833 - 835 (2008/09/21)
A copper-catalyzed method for the preparation of ynamides has been identified that proceeds via aerobic oxidative coupling of terminal alkynes with various nitrogen nucleophiles, including cyclic carbamates, amides and ureas, and N-alkyl-arylsulfonamides and indoles. Copyright
