1007864-56-3Relevant academic research and scientific papers
Syntheses of tetrahydrothiophenes and tetrahydrofurans and studies of their derivatives as melanocortin-4 receptor ligands
Tran, Joe A.,Chen, Caroline W.,Tucci, Fabio C.,Jiang, Wanlong,Fleck, Beth A.,Chen, Chen
, p. 1124 - 1130 (2008/09/18)
Piperazinebenzylamine derivatives from trans-4-(4-chlorophenyl)tetrahydrothiophene-3-carboxylic acid 6 and its S-oxide 7 and sulfone 8, and the tetrahydrofuran 9 and its two regioisomers 11 and 13 were synthesized and studied for their binding affinities at the human melanocortin-4 receptor. These five-membered ring constrained compounds possessed similar or lower potency compared to the acyclic analogs.
Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor
Chen, Chen,Jiang, Wanlong,Tran, Joe A.,Tucci, Fabio C.,Fleck, Beth A.,Markison, Stacy,Wen, Jenny,Madan, Ajay,Hoare, Sam R.,Foster, Alan C.,Marinkovic, Dragan,Chen, Caroline W.,Arellano, Melissa,Saunders, John
, p. 129 - 136 (2008/09/17)
A series of trans-4-phenylpyrrolidine-3-carboxamides were synthesized and characterized as potent ligands of the human melanocortin-4 receptor. Interestingly, a pair of diastereoisomers 13b displayed potent functional agonist and antagonist activity, resp
