1008-07-7

Basic information

• Product Name: 7-CHLORO-3-FORMYLINDOLE
• Synonyms: 7-CHLORO-3-FORMYLINDOLE;7-Chloro-3-indolecarboxaldehyde;1H-Indole-3-carboxaldehyde, 7-chloro-;7-Chloro-3-formyl-1H-indole
• CAS NO: 1008-07-7
• Molecular Formula: C₉H₆ClNO
• Molecular Weight: 179.61
• Mol File: 1008-07-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 373.4 °C at 760 mmHg
• Flash Point: 179.6 °C
• Appearance: /
• Density: 1.431 g/cm³
• Vapor Pressure: 8.99E-06mmHg at 25°C
• Refractive Index: 1.731
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 7-CHLORO-3-FORMYLINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CHLORO-3-FORMYLINDOLE(1008-07-7)
• EPA Substance Registry System: 7-CHLORO-3-FORMYLINDOLE(1008-07-7)

Safety Data

• Hazardous Substances Data: 1008-07-7(Hazardous Substances Data)

Usage

General Description

7-CHLORO-3-FORMYLINDOLE is a chemical compound with the molecular formula C9H6ClNO. It is a chlorinated formylindole derivative, which is a class of compounds that are often used in organic synthesis and medicinal chemistry research. This specific compound is characterized by a chloro group and a formyl group attached to a 3-substituted indole ring. It has potential applications in the development of pharmaceuticals and agrochemicals due to its unique chemical properties and structural features. 7-CHLORO-3-FORMYLINDOLE may be used as a building block in the synthesis of other complex organic molecules or as a starting material for the creation of new chemical entities with biological activity. Studies on its synthesis, properties, and potential biological or industrial applications are likely to be of interest to researchers in the field of organic chemistry and drug discovery.

InChI:InChI=1/C9H6ClNO/c10-8-3-1-2-7-6(5-12)4-11-9(7)8/h1-5,11H

Upstream product

• 53924-05-3 7-chloro-1H-indole 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 221377-37-3 7-chloro-1H-indole-3-acetonitrile 
• 1428968-84-6 1-(7-chloro-1H-indol-3-yl)-2-((2-methoxypyridin-4-yl)amino)-2-phenylethanone 
• 1428968-67-5 1-(7-chloro-1H-indol-3-yl)-2-((3-methoxyphenyl)amino)-2-phenylethanone 
• 1428969-08-7 4-(2-(7-chloro-1H-indol-3-yl)-1-((3-methoxyphenyl)amino)-2-oxoethyl)benzonitrile 
• 1422432-60-7 C₂₁H₁₆ClN₃O₃ 
• 1422433-23-5 C₂₃H₂₀ClN₃O₃ 
• 3804-16-8 2-(7-chloro-1H-indol-3-yl)ethanamine 
• 1195785-02-4 C₁₈H₁₃ClN₄ 
• 852391-19-6 Nec-1s 

Relevant articles and documents

Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles

Three isomers of chloro-3-(2-pyridin-3-ylvinyl)-1H-indole were synthesized and tested as inhibitors of human tryptophan 2,3-dioxygenase (hTDO). The crystal structures of two of them were solved by X-ray diffraction. The solubility of the molecules also was determined experimentally. The molecular electrostatic potentials and dipole moments of the three isomers were calculated by ab initio quantum mechanics (HF/6-311G). The single crystal X-ray analyses reveal non-planar structures. This non-coplanarity is retained during docking of the compounds into a model of hTDO, the molecular target of this series. The position of the Cl atom does not significantly affect the electronic delocalization. Nevertheless, the position of the Cl atom produces a local variation of bond lengths inducing different dipole moments for these isomers. Variations in dipole moments are consistent with the different melting points and crystal packings. Differences in aqueous solubilities are best explained by subtle changes in H-bonds resulting from different accessibilities of the indole NH's due to steric effects of the Cl substituent. The non-coplanarity plays an important role in the crystalline packing of the molecules in contrast to the position of the Cl. This study leads to a better understanding of the structural and electronic characteristics of this chemical series and can potentially help to better understand their inhibitory activity.

DUAL-INHIBITORS OF CELLULAR NECROPTOSIS AND FERROPTOSIS FOR USE IN THE TREATMENT OF ORGAN TRANSPLANT PATIENTS

The invention relates to chemical compounds for use as a medicament in the prevention of organ transplant rejection and/or transplant organ damage. In embodiments of the invention, the compound inhibits and/or reduces ferroptosis and necroptosis of cells of the transplanted organ. In further embodiments, the patient is at risk of transplant rejection and/or is at risk of or shows signs of ischemia-reperfusion injury and/or necroinflammation.

BICYCLIC HETEROAROMATIC UREA OR CARBAMATE COMPOUNDS FOR USE IN THERAPY

The present invention relates to bicyclic heteroaromatic urea or carbamate compounds of formula I where the variables are as defined in the claims and the description. The invention moreover relates to a pharmaceutical composition containing these compounds I, and to these compounds for use in therapy, especially for use in the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularization.