1008105-72-3

Upstream product

• 536-74-3 phenylacetylene 
• 1761-61-1 5-bromosalicyclaldehyde 
• 106-41-2 4-bromo-phenol 

Downstream Products

• 1008105-81-4 (Z)-2-benzylidene-5-bromo-2,3-dihydrobenzofuran-3-ol 
• 1218-80-0 6-bromoflavone 
• 862707-88-8 C₁₅H₉BrO₂ 
• 109619-11-6 1-(5-bromo-2-hydroxyphenyl)-3-phenylprop-2-yn-1-one 
• 59931-51-0 2-benzyl-5-bromobenzofuran 
• 1008105-88-1 (Z)-2-benzylidene-5-bromobenzofuran-3(2H)-one 

Relevant academic research and scientific papers

Metal-Free One-Pot Synthesis of 3-Phosphinoylbenzofurans via Phospha-Michael Addition/Cyclization of H-Phosphine Oxides and in Situ Generated ortho-Quinone Methides

A novel metal-free one-pot protocol for the effective and efficient synthesis of 3-phosphinoylbenzofurans via a phospha-Michael addition/cyclization of H-phosphine oxides and in situ generated ortho-quinone methides is described. Based on the expeditious

Lewis Acid Catalyzed Tandem 1,4-Conjugate Addition/Cyclization of in Situ Generated Alkynyl o-Quinone Methides and Electron-Rich Phenols: Synthesis of Dioxabicyclo[3.3.1]nonane Skeletons

A versatile Lewis acid catalyzed tandem cyclization of in situ generated alkynyl o-quinone methides (o-AQMs) with electron-rich phenols has been developed on the basis of the mode involving an intermolecular 1,4-conjugate addition/6-endo cyclization/1,3-a

A novel cyclization/oxidation strategy for a two-step synthesis of (Z)-aurone

An efficient and facile two-step strategy for the synthesis of (Z)-aurone from arylacetylenes and salicyladehydes, via silver(I) nitrate mediated cyclization/oxidation in the presence of potassium carbonate has been developed. The key feature of our metho

Synthesis method of aurone compound

The invention discloses a synthesis method of an aurone compound. The synthesis method comprises the following steps of (1) uniformly stirring phenylacetylene and a phenylacetylene derivative, slowly dripping n-butyllithium, reacting for 30min, and drippi

Directing group assisted nucleophilic substitution of propargylic alcohols via o -quinone methide intermediates: Br??nsted acid catalyzed, highly enantio- and diastereoselective synthesis of 7-alkynyl-12a-acetamido-substituted benzoxanthenes

BINOL-based, chiral phosphoric acids catalyze the substitution of 1-(o-hydroxyphenyl)propargylic alcohols with enamides to furnish 7-alkynyl-12a-acetamido-substituted benzo[c]xanthenes and related heterocycles in a one-pot operation with excellent diastereo- and enantioselectivity. Ambient reaction temperature, operationally simple reaction conditions, low catalyst loading, high yields, and excellent stereocontrol are attractive features of this process and make it a highly practical and versatile transformation.

Synthesis of chromones through LiOtBu/air-mediated oxidation and regioselective cyclization of o-hydroxyphenyl propargyl carbinols

A cascade oxidative cyclization reaction for the synthesis of chromone derivatives was developed by using LiOtBu as a mediator and air as an oxidant. The reaction was carried out without the assistance of a transition metal under mild conditions to afford the chromones in good yields with high regioselectivities. A tandem reaction for the synthesis of various chromones was developed. LiOtBu was used as a mediator and air was used as a clean oxidant. The reaction generally showed high regioselectivity under mild conditions. Extensive research showed that dehydrogenative oxidation of the alcohols under strongly basic conditions was the crucial step, and Li+ was also found to play an important role in this process. Copyright

Water-promoted, silver-phosphine complex-catalyzed stereoselective cyclization of 2-(1-Hydroxy-3-arylprop-2-ynyl)phenols leading to a highly efficient approach to aurones

Silver-phosphine complexes can be utilized as highly efficient catalysts for the cyclization of 2-(1-hydroxy-3-arylprop-2-ynyl)phenols (1) to give product 2, key intermediates to synthesize aurones (4), with good yields and stereoselectivities in water-to

Versatile and expeditious synthesis of aurones via AuI-catalyzed cyclization

(Chemical Equation Presented) Aurones are conveniently formed in a three-step procedure including a goldI-catalyzed cyclization of 2-(1-hydroxyprop-2-ynyl)phenols as a highly regio- and stereoselective key step. A wide diversity of derivatives can be obtained starting from substituted salicylaldehydes. Synthesis of natural 4,6,3′,4′-tetramethoxyaurone and structure revision of two natural products (dalmaisione D and 4′-chloroaurone) were achieved.