1008115-43-2Relevant academic research and scientific papers
Azaxanthene based selective glucocorticoid receptor modulators: Design, synthesis, and pharmacological evaluation of (S)-4-(5-(1-((1,3,4-Thiadiazol-2- yl)amino)-2-methyl-1-oxopropan-2-yl)-5 H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro- N, N-dimethylbenzamide (
Weinstein, David S.,Gong, Hua,Doweyko, Arthur M.,Cunningham, Mark,Habte, Sium,Wang, Jin Hong,Holloway, Deborah A.,Burke, Christine,Gao, Ling,Guarino, Victor,Carman, Julie,Somerville, John E.,Shuster, David,Salter-Cid, Luisa,Dodd, John H.,Nadler, Steven G.,Barrish, Joel C.
, p. 7318 - 7333 (2011)
Structurally novel 5H-chromeno[2,3-b]pyridine (azaxanthene) selective glucocorticoid receptor (GR) modulators have been identified. A screening paradigm utilizing cellular assays of GR-mediated transrepression of proinflammatory transcription factors and
MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF
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Page/Page column 117, (2009/04/24)
Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including inflammatory and immune diseases, having the structure of formula (I): an en
