100814-57-1

Basic information

• Product Name: 2(1H)-Pyrimidinone,4-amino-5-fluoro-5,6-dihydro-6-hydroxy-,cis-(9CI)
• Synonyms: 2(1H)-Pyrimidinone,4-amino-5-fluoro-5,6-dihydro-6-hydroxy-,cis-(9CI)
• CAS NO: 100814-57-1
• Molecular Formula: C₄H₆FN₃O₂
• Molecular Weight: 147.11
• Product Categories: HALIDE
• Mol File: 100814-57-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2(1H)-Pyrimidinone,4-amino-5-fluoro-5,6-dihydro-6-hydroxy-,cis-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrimidinone,4-amino-5-fluoro-5,6-dihydro-6-hydroxy-,cis-(9CI)(100814-57-1)
• EPA Substance Registry System: 2(1H)-Pyrimidinone,4-amino-5-fluoro-5,6-dihydro-6-hydroxy-,cis-(9CI)(100814-57-1)

Safety Data

• Hazardous Substances Data: 100814-57-1(Hazardous Substances Data)

Usage

Chemical Class

Pyrimidinone

Heterocyclic compound

Yes

Contains

Different sources of media describe the Contains of 100814-57-1 differently. You can refer to the following data:
1. Pyrimidine ring
2. Fluorine atom
3. Amino group

Configuration

cis

Functional groups location

Same side of the molecule

Potential applications

Pharmaceuticals

Biological activity

Possible

Further research needed

Yes

Upstream product

• 64-19-7 acetic acid 
• 71-30-7 cytosine 

Relevant articles and documents

Glorination of Pyrimidines. Part 2. Mechanistic Aspects of the Reaction of Acetyl Hypofluorite with Uracil and Cytosine Derivatives

The reaction of acetyl hypofluorite (AcOF) with uracil, cytosine, and some N-1-substituted derivatives dissolved in either acetic acid or water has been investigated.Analysis by radio-h.p.l.c., using (18)f as a tracer, and by (1)H n.m.r. revealed that a substituent at N-1 of uracil has a remarkable effect on the stability of the intermediate 6-acetoxy-5-fluoro-5,6-dihydrouracils.In addition, it was found that these cytosine adducts rapidly deaminate in water yielding their corresponding uracil analogues.