1008355-79-0

Basic information

• Product Name: 2-[4-(2-bromo-4,5-dimethoxybenzyloxy)phenyl]-1-t-butyldimethylsilyloxyethane
• Synonyms: 2-[4-(2-bromo-4,5-dimethoxybenzyloxy)phenyl]-1-t-butyldimethylsilyloxyethane
• CAS NO: 1008355-79-0
• Molecular Weight: 481.502
• Mol File: 1008355-79-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[4-(2-bromo-4,5-dimethoxybenzyloxy)phenyl]-1-t-butyldimethylsilyloxyethane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(2-bromo-4,5-dimethoxybenzyloxy)phenyl]-1-t-butyldimethylsilyloxyethane(1008355-79-0)
• EPA Substance Registry System: 2-[4-(2-bromo-4,5-dimethoxybenzyloxy)phenyl]-1-t-butyldimethylsilyloxyethane(1008355-79-0)

Safety Data

• Hazardous Substances Data: 1008355-79-0(Hazardous Substances Data)

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 54370-00-2 2-bromo-4,5-dimethoxybenzyl alcohol 
• 53207-00-4 1-bromo-2-(bromomethyl)-4,5-dimethoxybenzene 
• 96013-75-1 2-(4{[tert-butyl(dimethyl)silyl]oxy}phenyl)ethanol 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 

Downstream Products

• 1008355-80-3 2-[4-(2-bromo-4,5-dimethoxybenzyloxy)phenyl]ethan-1-ol 

Relevant articles and documents

Intermolecular silyl migration reactions

Sodium hydride promoted O-alkylation of 2-[(4-t-butyldimethylsilyloxy) phenyl]ethan-1-ol with 1-bromo-2-(bromomethyl)-4,5-dimethoxybenzene depend on the solvent used in the coupling reaction. Mixtures of 2-[4-(2-bromo-4,5- dimethoxybenzyloxy)phenyl]-1-t-butyldimethylsilyloxyethaneand2-[4-(2-bromo-4, 5-dimethoxybenzyloxy)phenyl] ethan-1-ol (in DMF), or 2-[4-(2-bromo-4,5- dimethoxybenzyloxy)phenyl]-1-t-butyldimethylsilyloxyethane and 4-[2-(2-bromo-4,5-dimethoxybenzyloxy)ethyl]phenol (in THF), were detected. These results can be explained by an unusual intermolecular silyl migration reaction.