Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1008361-81-6

Post Buying Request

1008361-81-6 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1008361-81-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1008361-81-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,8,3,6 and 1 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1008361-81:
(9*1)+(8*0)+(7*0)+(6*8)+(5*3)+(4*6)+(3*1)+(2*8)+(1*1)=116
116 % 10 = 6
So 1008361-81-6 is a valid CAS Registry Number.

1008361-81-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-Bromo-7-chloro-1H-benzoimidazole

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1008361-81-6 SDS

1008361-81-6Downstream Products

1008361-81-6Relevant articles and documents

Structure-Guided Design of Group i Selective p21-Activated Kinase Inhibitors

Crawford, James J.,Lee, Wendy,Aliagas, Ignacio,Mathieu, Simon,Hoeflich, Klaus P.,Zhou, Wei,Wang, Weiru,Rouge, Lionel,Murray, Lesley,La, Hank,Liu, Ning,Fan, Peter W.,Cheong, Jonathan,Heise, Christopher E.,Ramaswamy, Sreemathy,Mintzer, Robert,Liu, Yanzhou,Chao, Qi,Rudolph, Joachim

, p. 5121 - 5136 (2015/07/02)

The p21-activated kinases (PAKs) play important roles in cytoskeletal organization, cellular morphogenesis, and survival and have generated significant attention as potential therapeutic targets for cancer. Following a high-throughput screen, we identified an aminopyrazole scaffold-based series that was optimized to yield group I selective PAK inhibitors. A structure-based design effort aimed at targeting the ribose pocket for both potency and selectivity led to much-improved group I vs II selectivity. Early lead compounds contained a basic primary amine, which was found to be a major metabolic soft spot with in vivo clearance proceeding predominantly via N-acetylation. We succeeded in identifying replacements with improved metabolic stability, leading to compounds with lower in vivo rodent clearance and excellent group I PAK selectivity.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1008361-81-6