100840-89-9Relevant academic research and scientific papers
Structural studies of pterin-based inhibitors of dihydropteroate synthase
Hevener, Kirk E.,Yun, Mi-Kyung,Qi, Jianjun,Kerr, Iain D.,Babaoglu, Kerim,Hurdle, Julian G.,Balakrishna, Kanya,White, Stephen W.,Lee, Richard E.
supporting information; experimental part, p. 166 - 177 (2010/04/29)
Dihydropteroate synthase (DHPS) is a key enzyme in bacterial folate synthesis and the target of the sulfonamide class of antibacterials. Resistance and toxicities associated with sulfonamides have led to a decrease in their clinical use. Compounds that bi
