1008448-19-8

Basic information

• Product Name: GTx-134
• Synonyms: GTx-134;2-[4-[[(2R)-3-(2,4-Dimethylphenoxy)-2-hydroxypropyl]amino]-1,2-dihydro-2-oxo-3-pyridinyl]-6,7-dihydro-6-[1-[2-(methylsulfonyl)ethyl]-4-piperidinyl]pyrrolo[3,4-f]benzimidazol-5(3H)-one
• CAS NO: 1008448-19-8
• Molecular Formula: C33H40N6O6S
• Molecular Weight: 648.7723
• Mol File: 1008448-19-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.43
• CAS DataBase Reference: GTx-134(CAS DataBase Reference)
• NIST Chemistry Reference: GTx-134(1008448-19-8)
• EPA Substance Registry System: GTx-134(1008448-19-8)

Safety Data

• Hazardous Substances Data: 1008448-19-8(Hazardous Substances Data)

Usage

General Description

GTx-134 is a selective androgen receptor modulator (SARM) that is being developed for the treatment of muscle atrophy and other conditions related to muscle wasting. It has a high affinity for the androgen receptor and has shown promising results in preclinical studies for increasing muscle mass and strength without the unwanted side effects commonly associated with traditional anabolic steroids. GTx-134 has the potential to be used in a variety of medical conditions where muscle wasting is a significant concern, such as cancer cachexia, sarcopenia, and certain genetic disorders. Clinical trials are ongoing to further evaluate its efficacy and safety for use in humans.

Upstream product

• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 59827-85-9 5-amino-6-nitroisoindoline-1,3-dione 
• 1008450-44-9 (R)-1-amino-3-(2,4-dimethylphenoxy)propan-2-ol 
• 3680-02-2 methyl ethenyl sulphone 

Relevant articles and documents

A Practical and Scalable Synthesis of GTx-134, an IGF-1R Inhibitor

A practical and scalable synthesis of GTx-134, a novel small-molecule inhibitor of insulin-like growth factor 1 receptor showing antitumor activity in preclinical models of multiple myeloma, is reported.