100847-62-9Relevant articles and documents
Fluorinated Retinoids via Crossed Aldol Condensation of 1,1,1-Trifluoroacetone
Mead, Dennis,Loh, Rhonda,Asato, A. E.,Liu, R. S. H.
, p. 2873 - 2876 (2007/10/02)
Piperidine-acetic acid catalyzed crossed aldol condensation of 1,1,1-trifluoroacetone with aryl or α,β-unsaturated aldehydes was found to be a useful method for the preparation of unsaturated trifluoromethyl ketones.Chain extension of these ketones led to several new fluorinated retinoids including the hitherto elusive all-trans isomers of 19,19,19- and 20,20,20-trifluororetinal.