1008508-98-2Relevant academic research and scientific papers
Substituted piperidines as HDM2 inhibitors
Ma, Yao,Lahue, Brian R.,Shipps Jr., Gerald W.,Brookes, Jeseca,Wang, Yaolin
, p. 1026 - 1030 (2014/03/21)
Novel small molecule HDM2 inhibitor, substituted piperidine, was identified. Initial SAR study indicated potential for several position optimizations. Additional potency enhancement was achieved by introducing a sidechain off the aromatic ring. DMPK study
Substituted Piperidines that Increase P53 Activity and the Uses Thereof
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Page/Page column 61, (2008/06/13)
In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.
