1008524-27-3Relevant academic research and scientific papers
Fused thiophene derivatives as MEK inhibitors
Laing, Victoria E.,Brookings, Daniel C.,Carbery, Rachel J.,Simorte, Jose Gascon,Hutchings, Martin C.,Langham, Barry J.,Lowe, Martin A.,Allen, Rodger A.,Fetterman, Joanne R.,Turner, James,Meier, Christoph,Kennedy, Jeff,Merriman, Mark
, p. 472 - 475 (2012/03/11)
A number of novel fused thiophene derivatives have been prepared and identified as potent inhibitors of MEK. The SAR data of selected examples and the in vivo profiling of compound 13h demonstrates the functional activity of this class of compounds in HT-
FUSED THIOPHENE DERIVATIVES AS MEK INHIBITORS
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Page/Page column 54, (2008/06/13)
A series of 4,5,6,7-tetrahydrothieno[2,3-c]azepin-8-one derivatives, and analogues thereof, which are substituted in the 2-position by a substituted anilino moiety, being selective inhibitors of human MEK (MAPKK) enzymes, are accordingly of benefit in med
