1008531-10-9Relevant academic research and scientific papers
Microwave assisted ring-opening of epoxides with N-biaryl sulfonamides in the synthesis of matrix metalloproteinase-9 inhibitors
Yang, Shyh-Ming,Murray, William V.
, p. 835 - 839 (2008)
A microwave accelerated epoxide ring-opening process with N-biaryl sulfonamides is described. Under this mild, highly efficient condition, an α-hydroxy-β-N-biaryl sulfonamide skeleton is rapidly assembled leading ultimately to a novel series of matrix met
β-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: Part 1. Design, synthesis, and lead identification
Yang, Shyh-Ming,Scannevin, Robert H.,Wang, Bingbing,Burke, Sharon L.,Wilson, Lawrence J.,Karnachi, Prabha,Rhodes, Kenneth J.,Lagu, Bharat,Murray, William V.
, p. 1135 - 1139 (2008/12/22)
A new series of β-N-biaryl ether sulfonamide hydroxamates as novel gelatinase inhibitors is described. These compounds exhibit good potency for MMP-2 and MMP-9 without inhibiting MMP-1. The structure-activity relationships (SAR) reveal the biaryl ether ty
MATRIX METALLOPROTEASE INHIBITORS
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Page/Page column 49; 53; 82, (2010/11/30)
The present invention relates to compounds of Formula I, wherein R1, R2, R3, R4, R5, R6, and R7 are defined in the specification. In addition, the present invention relates to methods treating disorders related to matrix metalloproteases. More particularl
