100859-84-5

Basic information

• Product Name: 2-CHLOROISONICOTINAMIDE
• Synonyms: 2-CHLOROPYRIDINE-4-CARBOXAMIDE;2-CHLOROISONICOTINAMIDE;BUTTPARK 43\57-02;2-Chloropyridine-4-carboxamide, 98+%;2-carbaMoyl-2-chloro-1,2-dihydropyridine-4-carboxylic acid;2-chloropyridin-4-carboxaMide;C257;Oprea1_265572
• CAS NO: 100859-84-5
• Molecular Formula: C₆H₅ClN₂O
• Molecular Weight: 156.57
• Product Categories: Pyridines;amine|alkyl chloride
• Mol File: 100859-84-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 198 °C
• Boiling Point: 312.2°C at 760 mmHg
• Flash Point: 142.6°C
• Appearance: /
• Density: 1.381g/cm³
• Vapor Pressure: 0.000535mmHg at 25°C
• Refractive Index: 1.588
• PKA: 14.37±0.50(Predicted)
• CAS DataBase Reference: 2-CHLOROISONICOTINAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROISONICOTINAMIDE(100859-84-5)
• EPA Substance Registry System: 2-CHLOROISONICOTINAMIDE(100859-84-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 100859-84-5(Hazardous Substances Data)

Usage

General Description

2-Chloroisonicotinamide is a chemical compound with the molecular formula C6H5ClN2O. It is a derivative of isonicotinamide, which is a structural isomer of nicotinamide. 2-Chloroisonicotinamide is a white to yellow crystalline solid with a melting point of 166-167°C. It is used as an intermediate for the synthesis of pharmaceuticals and agrochemicals. The compound has been studied for its potential as an anti-tuberculosis agent and for its use in the treatment of cancer. It can also be used as a building block in the production of other organic compounds.

InChI:InChI=1/C6H5ClN2O/c7-5-3-4(6(8)10)1-2-9-5/h1-3H,(H2,8,10)

Upstream product

• 33252-30-1 2-chloro-4-pyridinenitrile 
• 6313-54-8 2-chloroisonicotinic acid, 
• 65287-34-5 2-chloropyridine-4-carbonyl chloride 

Downstream Products

• 1589084-96-7 4-{5-cyclopropyl-2-[2-(2-fluorophenylamino)pyridin-4-yl]pyrido[3,4-d]pyrimidin-4-yl}piperazine-1-carboxylic acid tert-butyl ester 
• 1589084-95-6 4-{5-chloro-2-[2-(2-fluorophenylamino)pyridin-4-yl]pyrido[3,4-d]pyrimidin-4-yl}piperazine-1-carboxylic acid tert-butyl ester 
• 1588952-76-4 [4-(5-cyclopropyl-4-piperazin-1-ylpyrido[3,4-d]pyrimidin-2-yl)pyridin-2-yl]-(2-fluorophenyl)amine 
• 1589084-94-5 4-[5-chloro-2-(2-phenylaminopyridin-4-yl)pyrido[3,4-d]pyrimidin-4-yl]piperazine-1-carboxylic acid tert-butyl ester 
• 1588952-59-3 [4-(5-chloro-4-piperazin-1-ylpyrido[3,4-d]pyrimidin-2-yl)pyridin-2-yl]phenylamine 
• 91447-89-1 2-chloropyridine-4-carbothioamide 
• 652153-37-2 (3-chlorophenyl)-[4-(2-chloropyridin-4-yl)-[1,3,5]triazin-2-yl]amine 
• 652153-35-0 3-((4-(4-((3-chlorophenyl)amino)-1,3,5-triazin-2-yl)-2-pyridinyl)amino)-1-propanol 

Relevant articles and documents

Cs2CO3 in pyrrolidinone promoted hydration of functionalized (hetero)aryl nitriles under metal-free conditions

An efficient hydration reaction of various (hetero)aryl nitriles using Cs2CO3 in pyrrolidinone is described. This new metal-free protocol proved to be highly effective and general to synthesize a variety of (hetero)aryl amides.

Efficient and selective nitrile hydration reactions in water catalyzed by an unexpected dimethylsulfinyl anion generated in situ from CsOH and DMSO

Unexpected dimethylsulfinyl anions (I), generated in situ from the superbase system CsOH-DMSO, was found to be a highly active catalyst for controllable nitrile hydration reactions in water, which selectively afforded the versatile amides via interesting Cs-activated I-catalyzed direct and indirect hydration mechanisms involving an O-transfer process from DMSO onto the nitriles. the Partner Organisations 2014.

A pyridine amide synthetic method of compound

The invention discloses a method for synthesizing a pyridine-amide compound. The method comprises the steps of carrying out hydrolysis on a pyridine cyanogen compound shown by a formula II as a starting material in water as a solvent in the presence of an ETS-10 molecular sieve as a catalyst, heating to 100-150 DEG C, reacting until the reaction, which is tracked and detected by virtue of TLC (Thin-Layer Chromatography), is completed and carrying out post-treatment on the reaction solution to obtain the pyridine-amide compound represented by the formula I. According to the method disclosed by the invention, the ETS-10 molecular sieve is taken as a catalyst to carry out hydrolysis on pyridine cyanogen to obtain a single pyridine-amide product, the conversion rate is 100%, the yield is above 95% and the catalyst can be repeatedly used for at least 5 times.