100867-08-1

Basic information

• Product Name: Benzene, 1-methoxy-4-[(4-nitrophenyl)methoxy]-
• CAS NO: 100867-08-1
• Molecular Formula: C14H13NO4
• Molecular Weight: 259.262
• Mol File: 100867-08-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, 1-methoxy-4-[(4-nitrophenyl)methoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methoxy-4-[(4-nitrophenyl)methoxy]-(100867-08-1)
• EPA Substance Registry System: Benzene, 1-methoxy-4-[(4-nitrophenyl)methoxy]-(100867-08-1)

Safety Data

• Hazardous Substances Data: 100867-08-1(Hazardous Substances Data)

Upstream product

• 150-76-5 4-methoxy-phenol 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 1122-95-8 sodium 4-methoxyphenolate 
• 123-31-9 hydroquinone 
• 619-73-8 4-nitrobenzyl chloride 

Downstream Products

• 150-76-5 4-methoxy-phenol 
• 13245-59-5 4-methoxyphenyl 4-nitrobenzoate 

Relevant articles and documents

Polymer-supported triphenylphosphine ditriflate: A novel dehydrating reagent

A new type of polymeric dehydrating reagent, readily prepared by the treatment of polymer-supported triphenylphosphine oxide with triflic anhydride, was found to be effective in a variety of dehydration reactions such as ester and amide formation; the polymer-supported triphenylphosphine oxide was easily recovered and reused several times without the loss of activity.

Novel polymer-supported coupling/dehydrating reagents for use in organic synthesis

Two novel dehydrating reagents 3 and 4, based on a phosphonium anhydride and an oxyphosphonium triflate respectively, were prepared by reaction of the corresponding polymer-supported phosphine oxides with triflic anhydride. Reagent 3, based on the novel phosphorus heterocycle 1,1,3,3-tetraphenyl-2-oxa-1,3- diphospholanium bis(trifluoromethanesulfonate), was found to be a useful reagent for ester and amide formation. A wide range ofcoupling/dehydration-type reactions, such as ester, amide, anhydride, peptide, ether and nitrile formation, were performed in high yield using the more readily prepared polymer-supported triphenylphosphine ditrinate 4, which was easily recovered and re-used several times without loss of efficiency. With primary alcohols, both reagents 3 and 4 provide an alternative to the Mitsunobu reaction, where the use of azodicarboxylates and chromatography to remove the phosphine oxide by-product can be avoided. The use of 4-dimethylaminopyridine allowed the esterification of secondary alcohols with 4 to proceed in high yield but with retention of configuration.

The α-Effect in Benzyl Transfers from Benzylphenylmethyl Sulfonium Salts to N-Methylbenzohydroxamate Anions

The investigation of the occurrence of the α-effect in group transfers from phenyldialkyl sulfonium ions where one alkyl group is benzyl allows an assay of the effect of changing the nature of the C atom being transferred. The size of the α-effect responds to increasing electron demand, as methyl transfers do. Quantitative relationships between the size of the α-effect are established from both the nucleophilic side and the leaving group side of the SN2 transition state.