100872-65-9Relevant articles and documents
Preparation method of moxifloxacin important intermediate (by machine translation)
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Page/Page column 5-7, (2019/10/01)
The invention discloses a preparation method, of an important intermediate of moxifloxacin. 2, 3 - Picolinic acid and acetic anhydride are charged first to the reaction kettle, stirred, and stirred to prepare a reaction feed liquid; a first reaction liquid is pumped into a continuous acid removal system filled with an acid remover, and then the reaction liquid is pumped into second reaction kettle; the second reaction kettle is used for stirring reaction; and after the reaction is finished, the reaction mixture liquid is stirred by 2nd. Concentration, a significant intermediate, namely compound 6 - benzyl - 555H-pyrrolo [3, 4 - b] pyridine -5, 7 - (6H) - diketone, is obtained under reduced pressure. The method effectively improves the conversion, greatly improves the yield, enhances the operability, realizes low energy consumption, and can realize the purpose. (by machine translation)
High-efficiency aminocarbonylation by introducing CO to a pressurized continuous flow reactor
Csajgi, Csaba,Borcsek, Bernadett,Niesz, Krisztin,Kovcs, Ildik,Szkelyhidi, Zsolt,Bajk, Zoltn,Rge, Lszl,Darvas, Ferenc
supporting information; experimental part, p. 1589 - 1592 (2009/04/07)
Halogenated aryl carboxylic acids were efficiently converted to the corresponding dicarboxylic acid monoamides by a one-step Pd-catalyzed aminocarbonylation in a micro/meso fluidic continuous flow reactor (X-Cube) operated at high pressure and high temperature with CO gas introduction. Reaction parameters (solvent, base, catalyst, pressure, temperature) were rapidly optimized in the reactions, which required less than 2 min. The method gave improved results over comparable batch techniques and is also suited to automated parallel syntheses of compound libraries.
