100875-69-2

Basic information

• Product Name: 4-[2-(4-METHYL-PIPERAZIN-1-YL)-ETHOXY]-BENZALDEHYDE
• Synonyms: TIMTEC-BB SBB011911;AKOS BC-2103;4-[2-(4-METHYL-PIPERAZIN-1-YL)-ETHOXY]-BENZALDEHYDE
• CAS NO: 100875-69-2
• Molecular Formula: C₁₄H₂₀N₂O₂
• Molecular Weight: 248.32
• Mol File: 100875-69-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 385.8±32.0 °C(Predicted)
• Appearance: /
• Density: 1.097±0.06 g/cm3(Predicted)
• PKA: 7.57±0.10(Predicted)
• CAS DataBase Reference: 4-[2-(4-METHYL-PIPERAZIN-1-YL)-ETHOXY]-BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(4-METHYL-PIPERAZIN-1-YL)-ETHOXY]-BENZALDEHYDE(100875-69-2)
• EPA Substance Registry System: 4-[2-(4-METHYL-PIPERAZIN-1-YL)-ETHOXY]-BENZALDEHYDE(100875-69-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 100875-69-2(Hazardous Substances Data)

Usage

General Description

4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-benzaldehyde is a chemical compound that is composed of a benzene ring attached to an aldehyde group and an ethoxy group, which is in turn connected to a piperazine ring with a methyl group attached. 4-[2-(4-METHYL-PIPERAZIN-1-YL)-ETHOXY]-BENZALDEHYDE is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It may also have potential applications in the fields of medicinal chemistry and drug discovery due to its unique structure and potential biological activities. Additionally, it is important to note that this compound should be handled with care and caution, as it may pose health and safety risks when not properly managed or used.

Upstream product

• 39123-20-1 1-(2-chloroethyl)-4-methylpiperazine 
• 109-01-3 1-methyl-piperazine 
• 54373-15-8 4-(2-chloroethoxy)benzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 
• 52191-15-8 4-(2-bromoethyloxy)benzaldehyde 

Downstream Products

• 1616111-02-4 (Z)-2-{4-[2-(4-methylpiperazin-1-yl)ethoxy]-benzylidene}-3-oxo-2,3-dihydrobenzofuran-7-carboxamide 
• 103157-10-4 1-[2-(4-fluoren-9-ylidenemethyl-phenoxy)-ethyl]-4-methyl-piperazine 

Relevant articles and documents

Design, synthesis and biological evaluation of novel 4-anlinoquinazoline derivatives as EGFR inhibitors with the potential to inhibit the gefitinib-resistant nonsmall cell lung cancers

A series of quinazoline derivatives with benzylidene hydrazine carboxamide were designed and synthesised as EGFR inhibitors. Most compounds exhibited exceptional anti-proliferative activity against A549, HepG2, MCF-7 and H1975 cells. Furthermore, six compounds demonstrated excellent inhibition activity against EGFRWT with the IC50 value both less than 2 nM. Among the six compounds, 44 exhibited the strongest activity (0.4 nM) and potently inhibited EGFRL858R/T790M (0.1 μM). Excitingly, the most potent compound 14 showed excellent enzyme inhibitory activity with 6.3 nM and 8.4 nM for both EGFRWT and EGFRT790M/L858R. The result of AO single staining and Annexin V/PI staining showed that the compound 14 and 44 could induce remarkable apoptosis of A549 cells. The compound 14 arrested the cell cycle at the S phase and compound 44 arrested the cell cycle at the G0 phase in A549 cells. These preliminary results demonstrate that compound 14 and 44 may be promising lead compound-targeting EGFR.

IMIDAZO [4, 5 - B] PYRIDINE DERIVATIVES AS ALK AND JAK MODULATORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS

This application relates to compounds of the Formula I as defined herein, and/or salts thereof. This application further relates to compositions and methods of using these compounds and/or salts thereof. The compounds of Formula I are useful as ALK and JAK modulators for the treatment of proliferative disorders.

4,6-diarylpyrimidine derivatives and salts thereof

Described are a 4,6-diarylpyrimidine derivative represented by the following formula (1): STR1 wherein R represents a heterocyclic ring which may be substituted by one to four lower alkyl groups or an amino group and Ar represents a phenyl, naphthyl or ar