1008796-53-9Relevant academic research and scientific papers
Titanium(IV)-promoted Mukaiyama aldol-Prins cyclizations
Patterson, Brian,Marumoto, Shinji,Rychnovsky, Scott D.
, p. 3163 - 3166 (2007/10/03)
(Matrix presented) A new version of the Mukaiyama aldol-Prins (MAP) cyclization has been developed. Unsaturated enol ethers such as 3 were found to couple with aldehydes in the presence of TiBr4 to give 4-bromotetrahydropyran products. This cascade reaction sequence leads to the formation of two new carbon-carbon bonds, a ring, and three new stereogenic centers. We expect this reaction to be a powerful new tool in synthesis.
