1008798-43-3

Basic information

• Product Name: N-[2-(3-{4-[(benzylethylamino)methyl]phenyl}-2-oxo-2H-chromen-6-yloxy)ethyl]-3-(3,4-difluorophenyl)propionamide
• CAS NO: 1008798-43-3
• Molecular Weight: 596.674
• Mol File: 1008798-43-3.mol

Chemical Properties

• CAS DataBase Reference: N-[2-(3-{4-[(benzylethylamino)methyl]phenyl}-2-oxo-2H-chromen-6-yloxy)ethyl]-3-(3,4-difluorophenyl)propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(3-{4-[(benzylethylamino)methyl]phenyl}-2-oxo-2H-chromen-6-yloxy)ethyl]-3-(3,4-difluorophenyl)propionamide(1008798-43-3)
• EPA Substance Registry System: N-[2-(3-{4-[(benzylethylamino)methyl]phenyl}-2-oxo-2H-chromen-6-yloxy)ethyl]-3-(3,4-difluorophenyl)propionamide(1008798-43-3)

Safety Data

• Hazardous Substances Data: 1008798-43-3(Hazardous Substances Data)

Upstream product

• 1008798-53-5 6-(2-aminoethoxy)-3-{4-[(benzylethylamino)methyl]phenyl}-chromen-2-one 
• 161712-75-0 3-(3,4-difluorophenyl)-propanoic acid 

Relevant articles and documents

Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

The complex etiology of Alzheimer's disease (AD) prompts scientists to develop multifunctional compounds to combat causes and symptoms of such neurodegeneration. To this aim we designed, synthesized, and tested a series of compounds by introducing halophenylalkylamidic functions on the scaffold of AP2238, which is a dual binding site acetylcholinesterase inhibitor. The inhibitory activity was successfully extended to the beta-site amyloid precursor protein cleavage enzyme, leading to the discovery of a potent inhibitor of this enzyme (3) and affording multifunctional compounds (2, 6, 8) for the treatment of AD.