1009-27-4 Usage
Uses
Used in Pharmaceutical Research and Development:
1H-Indole, 2-ethoxyis used as a key intermediate in the synthesis of various pharmaceutical compounds for its potential role in the development of new drugs. Its unique structure and biological activities contribute to the exploration of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 1H-Indole, 2-ethoxyserves as a valuable building block for the creation of complex organic molecules. Its reactivity and functional group compatibility make it suitable for a wide range of chemical reactions.
Used in Drug Development for Antitumor Properties:
1H-Indole, 2-ethoxyis utilized in drug development as an antitumor agent due to its demonstrated ability to inhibit tumor growth and progression. Its potential as a therapeutic agent is currently under investigation for various types of cancer.
Used in Drug Development for Anti-inflammatory Properties:
1H-Indole, 2-ethoxyis also used in the development of anti-inflammatory drugs, capitalizing on its capacity to reduce inflammation and alleviate symptoms associated with inflammatory conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1009-27-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,0 and 9 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1009-27:
(6*1)+(5*0)+(4*0)+(3*9)+(2*2)+(1*7)=44
44 % 10 = 4
So 1009-27-4 is a valid CAS Registry Number.
1009-27-4Relevant academic research and scientific papers
Golovko,Solov'Eva,Anisimova,Smirnova,Evstratova,Kiselev,Granik
, p. 177 - 185 (2008)
Condensation of indolin-2-one (oxindole) lactim ether with malononitrile leads to 2-dicyanomethylidene-2,3-dihydroindole, the reaction of which with dimethylformamide diethyl acetal (or with triethyl orthoformate) and the subsequent cyclization afford 4-c
Enantioselective and Diastereodivergent Synthesis of Spiroindolenines via Chiral Phosphoric Acid-Catalyzed Cycloaddition
Varlet, Thomas,Mati?i?, Mateja,Van Elslande, Elsa,Neuville, Luc,Gandon, Vincent,Masson, Géraldine
supporting information, p. 11611 - 11619 (2021/08/16)
A diastereodivergent and enantioselective synthesis of chiral spirocyclohexyl-indolenines with four contiguous stereogenic centers is achieved by a chiral phosphoric acid-catalyzed cycloaddition of 2-susbtituted 3-indolylmethanols with 1,3-dienecarbamates. Modular access to two different diastereoisomers with high enantioselectivities was obtained by careful choice of reaction conditions. Their functional group manipulation provides an efficient access to enantioenriched spirocyclohexyl-indolines and -oxindoles. The origins of this stereocontrol have been identified using DFT calculations, which reveal an unexpected mechanism compared to our previous work dealing with enecarbamates.
