1009086-50-3Relevant academic research and scientific papers
Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines
Douty, Brent,Wayland, Brian,Ala, Paul J.,Bower, Michael J.,Pruitt, James,Bostrom, Lori,Wei, Min,Klabe, Ronald,Gonneville, Lucie,Wynn, Richard,Burn, Timothy C.,Liu, Phillip C.C.,Combs, Andrew P.,Yue, Eddy W.
, p. 66 - 71 (2008/09/18)
The structure-based design and synthesis of isothiazolidinone (IZD) inhibitors of PTP1B containing imidazoles and imidazolines and their modification to interact with the B site of PTP1B are described here. The X-ray crystal structures of 3I and 4I comple
