100909-95-3

Basic information

• Product Name: (2,5-DiMethylfuran-3-yl)-acetic acid
• Synonyms: (2,5-DiMethylfuran-3-yl)-acetic acid
• CAS NO: 100909-95-3
• Molecular Formula: C8H10O3
• Molecular Weight: 154
• EINECS: -0
• Mol File: 100909-95-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2,5-DiMethylfuran-3-yl)-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2,5-DiMethylfuran-3-yl)-acetic acid(100909-95-3)
• EPA Substance Registry System: (2,5-DiMethylfuran-3-yl)-acetic acid(100909-95-3)

Safety Data

• Hazardous Substances Data: 100909-95-3(Hazardous Substances Data)

Usage

General Description

(2,5-Dimethylfuran-3-yl)-acetic acid is a chemical compound with the molecular formula C9H10O3. It consists of a furan ring with a methyl group at the 2 and 5 positions, and a carboxylic acid group attached to the furan ring. (2,5-Dimethylfuran-3-yl)-acetic acid is used as a building block in organic synthesis and can be used in the production of various pharmaceuticals, agrochemicals, and fine chemicals. It has also been studied for its potential as a biofuel due to its high energy density and low freezing point. Additionally, it is a versatile intermediate in the synthesis of a wide range of compounds.

Upstream product

• 10599-70-9 2,5-dimethyl-3-acetylfuran 
• 100909-75-9 2-[1-(5-Methyl-3-phenyl-[1,4,2]dioxazol-5-yl)-3-oxo-butyl]-malonic acid diethyl ester 
• 66310-18-7 4c-(5-methyl-3-phenyl-[1,4,2]dioxazol-5-yl)-but-3-en-2-one 
• 318511-74-9 methyl 3-acetyl-3-tert-butyloxycarbonyl-5-oxo-hexanoate 
• 318511-70-5 tert-butyl 2-acetyl-4-oxopentanoate 
• 318511-81-8 methyl 2-(2,5-dimethylfuran-3-yl)acetate 
• 100909-91-9 3-(dicarbethoxymethyl)-2,5-dimethylfuran 

Relevant articles and documents

Total Synthesis of Catunaregin and Preliminary Evaluation of Its Antitumor Activity

The total synthesis of catunaregin in both racemic and optically active forms was accomplished. The enantioselective synthesis uses the Evans aldol strategy, with an oxazolidinone or thiazolidinethione as the chiral auxiliary. The key features include a syn-selective aldol reaction to form the Evans-syn or non-Evans-syn product, and a successive ketalization reaction of a furanyl diol derivative under acidic conditions. The biological properties of the synthetic racemate and both enantiomers were evaluated against A549 and HL-60 human cancer cells.

Synthesis of tri- and tetrasubstituted furans catalyzed by trifluoroacetic acid

(matrix presented) Substituted 2-hydroxy-3-acetylfurans are synthesized by alkylation of tert-butyl acetoacetate with an α-haloketone followed by treatment of the obtained intermediate with trifluoroacetic acid (TFA). A second alkylation of the intermedia