100930-72-1Relevant academic research and scientific papers
Oxidative photocatalytic homo- And cross-coupling of phenols: Nonenzymatic, catalytic method for coupling tyrosine
Niederer, Kyle A.,Gilmartin, Philip H.,Kozlowski, Marisa C.
, p. 14615 - 14623 (2020/12/23)
An oxidative photocatalytic method for phenol? phenol homo- and cross-coupling is described, and isolated yields of 16?97% are obtained. Measured oxidation potentials and computed nucleophilicity parameters support a mechanism of nucleophilic attack of one partner onto the oxidized neutral radical form of the other partner. Our understanding of this model permitted the development of cross-coupling reactions between nucleophilic phenols/arenes and easily oxidized phenols with high selectivity and efficiency. A highlight of this method is that one equivalent of each coupling partner is utilized. Building on these findings, a nonenzymatic, catalytic method for coupling tyrosine was also developed.
