1009301-19-2Relevant academic research and scientific papers
Improved total synthesis of the potent HDAC inhibitor FK228 (FR-901228)
Greshock, Thomas J.,Johns, Deidre M.,Noguchi, Yasuo,Williams, Robert M.
, p. 613 - 616 (2008/09/16)
A scaleable synthesis of the potent histone deacetylase (HDAC) inhibitor FK228 is described. A reliable strategy for preparing the key β-hydroxy mercapto heptenoic acid partner was accomplished in nine steps and 13% overall yield. A Noyori asymmetric hydrogen-transfer reaction established the hydroxyl stereochemistry in >99:1 er via the reduction of a propargylic ketone.
