1009301-21-6

Basic information

• Product Name: C₅₂H₅₆N₄O₇S
• Synonyms: C₅₂H₅₆N₄O₇S
• CAS NO: 1009301-21-6
• Molecular Weight: 881.105
• Mol File: 1009301-21-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅₂H₅₆N₄O₇S(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₂H₅₆N₄O₇S(1009301-21-6)
• EPA Substance Registry System: C₅₂H₅₆N₄O₇S(1009301-21-6)

Safety Data

• Hazardous Substances Data: 1009301-21-6(Hazardous Substances Data)

Upstream product

• 1009301-30-7 (2S)-methyl 2-{(Z)-2-[(S)-2-amino-3-(tritylthio)propanamido]but-2-enamido}-3-methylbutanoate 
• 84624-17-9 N-(9-fluorenylmethoxycarbonyl)-D-valine 

Downstream Products

• 180973-32-4 (S)-2-{(Z)-2-[(S)-2-((R)-2-Amino-3-methyl-butyrylamino)-3-tritylsulfanyl-propionylamino]-but-2-enoylamino}-3-methyl-butyric acid methyl ester 

Relevant articles and documents

Improved total synthesis of the potent HDAC inhibitor FK228 (FR-901228)

A scaleable synthesis of the potent histone deacetylase (HDAC) inhibitor FK228 is described. A reliable strategy for preparing the key β-hydroxy mercapto heptenoic acid partner was accomplished in nine steps and 13% overall yield. A Noyori asymmetric hydrogen-transfer reaction established the hydroxyl stereochemistry in >99:1 er via the reduction of a propargylic ketone.