1009339-36-9

Basic information

• Product Name: dimethyl 4-(trifluoromethyl)pyridine-2,6-dicarboxylate
• Synonyms: dimethyl 4-(trifluoromethyl)pyridine-2,6-dicarboxylate
• CAS NO: 1009339-36-9
• Molecular Weight: 263.173
• Mol File: 1009339-36-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: dimethyl 4-(trifluoromethyl)pyridine-2,6-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 4-(trifluoromethyl)pyridine-2,6-dicarboxylate(1009339-36-9)
• EPA Substance Registry System: dimethyl 4-(trifluoromethyl)pyridine-2,6-dicarboxylate(1009339-36-9)

Safety Data

• Hazardous Substances Data: 1009339-36-9(Hazardous Substances Data)

Upstream product

• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 112776-84-8 4-iodo-2,6-pyridinedicarboxylic acid dimethyl ester 

Downstream Products

• 210155-50-3 2,6-(2,6-(i)Pr₂-C₆H₃N=CMe)2-4-CF₃-C₅H₂N 

Relevant articles and documents

Synthesis of 12-Membered Tetra-aza Macrocyclic Pyridinophanes Bearing Electron-Withdrawing Groups

The number of substituted pyridine pyridinophanes found in the literature is limited due to challenges associated with 12-membered macrocycle and modified pyridine synthesis. Most notably, the electrophilic character at the 4-position of pyridine in pyridinophanes presents a unique challenge for introducing electrophilic chemical groups. Likewise, of the few reported, most substituted pyridine pyridinophanes in the literature are limited to electron-donating functionalities. Herein, new synthetic strategies for four new macrocycles bearing the electron-withdrawing groups CN, Cl, NO2, and CF3 are introduced. Potentiometric titrations were used to determine the protonation constants of the new pyridinophanes. Further, the influence of such modifications on the chemical behavior is predicted by comparing the potentiometric results to previously reported systems. X-ray diffraction analysis of the 4-Cl substituted species and its Cu(II) complex are also described to demonstrate the metal binding nature of these ligands. DFT analysis is used to support the experimental findings through energy calculations and ESP maps. These new molecules serve as a foundation to access a range of new pyridinophane small molecules and applications in future work.

Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines

We report herein the asymmetric coupling of flow-generated unstabilized diazo compounds and propargylated amine derivatives, using a new pyridinebis(imidazoline) ligand, a copper catalyst and base. The reaction proceeds rapidly, generating chiral allenes in 10–20 minutes with high enantioselectivity (89–98 % de/ee), moderate yields and a wide functional group tolerance.

Catalytic enantioselective synthesis of tetrahydrofurans: a dynamic kinetic asymmetric [3 + 2] cycloaddition of racemic cyclopropanes and aldehydes

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