1009367-91-2Relevant academic research and scientific papers
Convenient synthesis of 1,4-dihydro-2H-3,1-benzoxazin-2-ones by iodocyclization of t-butyl 2-vinylphenylcarbamates
Kobayashi, Kazuhiro,Fukamachi, Shuhei,Nakamura, Daizo,Morikawa, Osamu,Konishi, Hisatoshi
, p. 95 - 105 (2008/09/20)
It has been found that t-butyl 2-vinylphenylcarbamate derivatives underwent iodocyclization on treatment with iodine in the presence of sodium hydrogencarbonate to afford 4-iodomethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one derivatives in generally good yields. The reduction of these 4-iodomethyl derivatives with tributyltin hydride gave the corresponding 4-methyl derivatives in good yields.
