1009372-99-9Relevant academic research and scientific papers
Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs)
Zhang, Yue-Mei,Fan, Xiaodong,Yang, Shyh-Ming,Scannevin, Robert H.,Burke, Sharon L.,Rhodes, Kenneth J.,Jackson, Paul F.
, p. 405 - 408 (2008/12/23)
Several classes of arylsulfone-based MMP-2/-9 inhibitors utilizing 6- to 8-membered heterocyclic rings as zinc-binding groups (ZBGs) have been synthesized and their enzyme inhibitory activities were evaluated. Although a number of 6- and 7-membered hetero
HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS
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Page/Page column 60, (2008/06/13)
This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
