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100938-10-1

Amastatin Hydrochloride, a peptide derivative, is a slow, tight binding, competitive aminopeptidase (AP) inhibitor. It was initially identified as an inhibitor of human serum AP-A (glutamyl AP) but does not inhibit AP-B (arginine AP). Amastatin Hydrochloride also inhibits various other aminopeptidases, including AP-N (AP-M, alanyl AP), leucyl-cystinyl AP, and endoplasmic reticulum AP 1. It is not effective against trypsin, papain, chymotrypsin, elastase, pepsin, or thermolysin.

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  • 100938-10-1 Structure

  • Basic information

    1. Product Name: AMASTATIN HYDROCHLORIDE
    2. Synonyms: H-(2S,3R)-AHMH-VAL-VAL-ASP-OH HCL;[(2S,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOYL]-VAL-VAL-ASP HYDROCHLORIDE;(2S,3R)-[3-AMINO-2-HYDROXY-5-METHYLHEXANOYL]-VAL-VAL-ASP-OH HCL;AMASTATIN;AMASTATIN HCL;AMASTATIN HYDROCHLORIDE;AMASTATIN HYDROCHLORIDE HYDRATE;N((2S 3R)3-AMINO-2-HXY-5-ME.HEXANOYL)-L&
    3. CAS NO:100938-10-1
    4. Molecular Formula: C21H39ClN4O8
    5. Molecular Weight: 511.01
    6. EINECS: 999-999-2
    7. Product Categories: Pepetides;peptides;inhibitor
    8. Mol File: 100938-10-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 795.1 °C at 760 mmHg
    3. Flash Point: 434.7 °C
    4. Appearance: White to off-white powder.
    5. Density: g/cm3
    6. Vapor Pressure: 3.14E-29mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: −20°C
    9. Solubility: methanol: 5 mg/mL, clear, colorless
    10. BRN: 8888370
    11. CAS DataBase Reference: AMASTATIN HYDROCHLORIDE(CAS DataBase Reference)
    12. NIST Chemistry Reference: AMASTATIN HYDROCHLORIDE(100938-10-1)
    13. EPA Substance Registry System: AMASTATIN HYDROCHLORIDE(100938-10-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. F: 10
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 100938-10-1(Hazardous Substances Data)

100938-10-1 Usage

Uses

Used in Pharmaceutical Industry:
Amastatin Hydrochloride is used as a pharmaceutical compound for its potent inhibitory effects on specific aminopeptidases. Its selective inhibition of these enzymes makes it a valuable tool in the development of drugs targeting various diseases and conditions.
Used in Research Applications:
In the field of research, Amastatin Hydrochloride serves as a valuable reagent for studying the function and role of aminopeptidases in biological processes. Its ability to selectively inhibit certain APs allows researchers to investigate the specific pathways and mechanisms involved in various cellular functions and diseases.
Used in Drug Development:
Amastatin Hydrochloride is used as a lead compound in the development of new drugs targeting aminopeptidases. Its unique properties and specificity make it a promising candidate for the creation of novel therapeutic agents for a range of medical conditions.
Used in Diagnostic Applications:
Amastatin Hydrochloride can be employed in diagnostic applications to identify and measure the activity of specific aminopeptidases in biological samples. This can be useful in the detection and monitoring of certain diseases or conditions where the activity of these enzymes is altered.

Biochem/physiol Actions

It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts angiotensin II to angiotensin III. Potentiates the CNS effects of vasopressin and oxytocin in vivo.Effective concentration: 1-10 μM.

Check Digit Verification of cas no

The CAS Registry Mumber 100938-10-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,9,3 and 8 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 100938-10:
(8*1)+(7*0)+(6*0)+(5*9)+(4*3)+(3*8)+(2*1)+(1*0)=91
91 % 10 = 1
So 100938-10-1 is a valid CAS Registry Number.
InChI:InChI=1/C21H38N4O8.ClH/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27;/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33);1H/t12-,13+,15+,16+,17+;/m1./s1

100938-10-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Amastatin hydrochloride hydrate

1.2 Other means of identification

Product number -
Other names AMASTATIN HYDROCHLORIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100938-10-1 SDS

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