100939-91-1 Usage
Description
1-(3-METHYL-BENZOYL)-PIPERAZINE is a chemical compound that belongs to the class of piperazine derivatives. It is a benzoyl derivative of piperazine and contains a methyl group attached to the benzoyl ring. 1-(3-METHYL-BENZOYL)-PIPERAZINE has potential applications in medicinal chemistry, particularly in the development of pharmaceutical drugs. Piperazine derivatives have been studied for their pharmacological properties, including their activity as central nervous system depressants, anthelmintics, and antihistamines. The 1-(3-methyl-benzoyl)-piperazine compound may have potential therapeutic uses and could be of interest for further research and development in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
1-(3-METHYL-BENZOYL)-PIPERAZINE is used as a compound for the development of pharmaceutical drugs due to its potential pharmacological properties.
Used in Medicinal Chemistry Research:
1-(3-METHYL-BENZOYL)-PIPERAZINE is used as a research compound for studying its potential therapeutic applications and pharmacological properties, such as its activity as central nervous system depressants, anthelmintics, and antihistamines.
Check Digit Verification of cas no
The CAS Registry Mumber 100939-91-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,9,3 and 9 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 100939-91:
(8*1)+(7*0)+(6*0)+(5*9)+(4*3)+(3*9)+(2*9)+(1*1)=111
111 % 10 = 1
So 100939-91-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H16N2O/c1-10-3-2-4-11(9-10)12(15)14-7-5-13-6-8-14/h2-4,9,13H,5-8H2,1H3
100939-91-1Relevant articles and documents
Expanding the structural diversity of Bcr-Abl inhibitors: Hybrid molecules based on GNF-2 and Imatinib
Pan, Xiaoyan,Dong, Jinyun,Shao, Ruili,Su, Ping,Shi, Yaling,Wang, Jinfeng,He, Langchong
, p. 4164 - 4168 (2015)
In order to expand the structural diversity of Bcr-Abl inhibitors, twenty hybrids (series E and P) have been synthesized and characterized based on Imatinib and GNF-2. Their biological activities were evaluated in vitro against human leukemia cells. Most compounds exhibited potent antiproliferative activity against K562 cells, especially for compounds E4, E5 and E7. Furthermore, these new hybrids were also screened for Abl kinase inhibitory activity, and some of them inhibited Abl kinase with low micromolar IC50 values. In particular, compound P3 displayed the most potent activity with IC50 value of 0.017 μM comparable with that of Imatinib. Molecular docking studies indicated that these novel hybrids fitted well with the active site of Bcr-Abl. These results suggested the great potential of these compounds as novel Bcr-Abl inhibitors.
Effect of Acyl Substituents on the Reaction Mechanism for Aminolyses of 4-Nitrophenyl X-Substituted Benzoates
Um, Ik-Hwan,Min, Ji-Sook,Ahn, Jung-Ae,Hahn, Hyun-Joo
, p. 5659 - 5663 (2007/10/03)
Second-order rate constants (kN) have been measured spectrophotometrically for the reaction of 4-nitrophenyl X-substituted benzoates with a series of alicyclic secondary amines in H2O containing 20 mol % dimethyl sulfoxide at 25.0°C.
