100950-24-1Relevant academic research and scientific papers
Synthesis of some biginelli compounds in solvent medium using a photochemistry method
Foroughifar,Mobinikhaledi,Fathinejad Jirandehi
, p. 495 - 500 (2003)
Some Biginelli compounds were synthesized by using a photochemistry method. The Biginell three-component cyclocondensation reactions in THF medium using a mixture of β-ketoester or β-diketone, arylaldehyde and (thio)urea under irradiation with a Wolframe
Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation
Kaoukabi, Hanane,Kabri, Youssef,Curti, Christophe,Taourirte, Moha,Rodriguez-Ubis, Juan C.,Snoeck, Robert,Andrei, Graciela,Vanelle, Patrice,Lazrek, Hassan B.
supporting information, p. 772 - 781 (2018/06/26)
By combining the structural features of dihydropyrimidinone and 1,2,3-triazole heterocycles, novel hybrid compounds were synthesized using a simple and convenient method. A series of novel mono and bis 1,2,3-triazole was synthesized via copper-catalyzed Huisgen azide-alkyne cycloadditions (CuAAC) under microwave irradiation. The newly synthesized compounds were evaluated for their antiviral activity against varicella-zoster virus (VZV). Compounds 6aa, 7ab, 6ba and 6da showed valuable antiviral activities, with EC50 values ranging from 3.6 to 11.3 μM against TK+ and TK- VZV and without measurable cell-growth inhibition.
QSAR analysis of 2-oxo-1,2,3,4-tetrahydropyrimidine analogues of antibacterials
Sawant, Ramesh L.,Bhatia, Manish S.
experimental part, p. 1361 - 1373 (2010/04/28)
QSAR analysis of two sets of analogues of 2-oxo-1,2,3,4- tetrahydropyrimidine was performed to investigate the relationship between their physicochemical parameters and antibacterial activity. Predictive and statistically significant models were generated
