100955-71-3Relevant academic research and scientific papers
Packed-bed reactors for continuous-flow C-N cross-coupling
Naber, John R.,Buchwald, Stephen L.
, p. 9469 - 9474 (2010)
Take a C-N bond and make it better: The optimized conditions for continuous-flow palladium-catalyzed C-N bond-forming reactions have been determined. They require the use of aqueous KOH, toluene as the solvent, tetrabutylammonium bromide as a phase-transfer catalyst, and a packed-bed microreactor (see scheme; TBAB=tetrabutylammonium bromide). In some cases, peforming these reactions under harsh conditions led to greatly enhanced reaction rates. Copyright
Copper-Catalyzed NaBAr 4-Based N-Arylation of Amines
Yang, Qin,Lei, Xiaoli,Yin, Zhijian,Deng, Zhihong,Peng, Yiyuan
supporting information, p. 538 - 544 (2019/01/10)
Using NaBAr 4 as an arylating agent, the formation of carbon-heteroatom bonds by a Cham-Lam cross-coupling reaction in the presence of catalytic copper(II) acetate monohydrate in acetonitrile at room temperature under air is described. The investigation of reaction scope suggests that several aliphatic and aromatic amines are compatible. In particular, the reaction of alkylamine and NaBAr 4 proceeds smoothly to offer the corresponding products in good to excellent yields.
