1009565-39-2

Upstream product

• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 684-16-2 Hexafluoroacetone 

Downstream Products

• 1009565-50-7 6-methoxy-2-phenyl-4-(trifluoromethyl)quinolin-3-ol 
• 1009565-52-9 6-methoxy-2-phenyl-4-(trifluoromethyl)quinoline-3-amine 
• 1009565-54-1 1-fluoro-8-methoxy-4-phenyl-3H-pyrazolo[3,4-c]quinoline 
• 1009565-49-4 6-methoxy-2-phenyl-3-[(1-phenylethenyl)oxy]-4-(trifluoromethyl)quinoline 
• 1009565-48-3 6-methoxy-2-phenyl-4-(trifluoromethyl)quinoline-3-carbonitrile 
• 1009565-51-8 3-ethoxy-6-methoxy-2-phenyl-4-(trifluoromethyl)quinoline 
• 1009565-53-0 6-methoxy-2-phenyl-3-(phenylsulfenyl)-4-(trifluoromethyl)quinoline 

Relevant academic research and scientific papers

One-pot synthesis of 3-fluoro-4-(trifluoromethyl)quinolines from pentafluoropropen-2-ol and their molecular modification

(Chemical Equation Presented) Pentafluoropropen-2-ol (PFP) was prepared by the reaction of hexafluoroacetone (HFA) with Mg/TMSCl. The one-pot tandem sequential reactions of PFP via Mannich addition with aldimines followed by Friedel-Crafts cyclization and aromatization afforded the title quinolines. A variety of corresponding 3-substituted quinolines were derived from the title quinoline by nucleophilic substitution of 3-fluorine with nucleophiles. A defluorinative transformation of the 4-trifluoromethyl group of the title quinoline with hydrazine afforded py razoloquinoline.