100958-53-0Relevant academic research and scientific papers
Biginelli reaction-carboxylic acids as catalysts
Noreen, Sadia,Perveen, Saima,Khan, Muhammad Naeem,Nazeer, Areesha,Khan, Misbahul Ain,Munawar, Munawar Ali,Babar, Rabia,Suhail, Farah,Azad, Muhammad,Bernardino, Alice M.R.,Dos Santos, Maurício S.
, p. 4770 - 4772 (2013)
Mono and dicarboxylic acids were found to be excellent catalysts for the synthesis of dihydropyrimidones/thiones. These are presented as alternate and cheap catalysts for the multicomponent reactions.
Regioselective chlorination at C-6 methyl position of 3,4-dihydropyrimidin- 2(1H)-ones using (dichloroiodo)benzene
Tale, Nilesh P.,Shelke, Amol V.,Bhong, Bhagyashree Y.,Karade, Nandkishor N.
, p. 981 - 986 (2013/07/26)
The reaction of (dichloroiodo)benzene with 4-aryl-1,2,3,4-tetrahydro-6- methyl-2-oxopyrimidine-5-carboxylates and 5-acetyl-4-aryl-3,4-dihydro-6- methylpyrimidin-2(1H)-ones resulted in geminal dichlorination at the C-6 methyl position of 3,4-dihydropyrimid
Yttria-zirconia-based Lewis acid catalysis of the Biginelli reaction: An efficient one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones
Ramalingam,Kumar, Pradeep
experimental part, p. 1299 - 1309 (2009/10/09)
Yttria-zirconia-based Lewis acid efficiently catalyzes the three-component cyclocondensation reaction of aldehyde, β-keto ester, and urea or thiourea in refluxing acetonitrile to produce the corresponding dihydropyrimidones in high yields. Copyright Taylor & Francis Group, LLC.
Synthesis of new 4-aryl-isoxazolo[5,4-d]pyrimidin-6-one(thione) and 4-aryl-pyrazolo[3,4-d]-pyrimidin-6-one derivatives of potential antihypertensive activity
El-Hamouly, Wageeh S.,El-Khamry, Abdel-Momen A.,Abbas, Eman M. H.
, p. 2091 - 2098 (2007/10/03)
Some aromatic aldehydes are subjected to react with urea (or thiourea) and acetyl acetone in a one-pot Biginelli-type cyclocondensation reaction to give 5-acetyl-4-aryl-6-methyl-1,2,3,4-tetrahydro-pyrimidines 2a-j. Aldehydes with ortho-hydroxy substituent
