100960-55-2Relevant articles and documents
"TRPV1 VANILLOID RECEPTOR ANTAGONISTS WITH A BICYCLIC PORTION"
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Page/Page column 92; 136, (2011/10/13)
The invention discloses compounds of formula I wherein Y is a group of formula A, B, C, D, or E: and W, Q, n, R1, R2, R3, U1-U5, J and K have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active
Rational design, synthesis, and structure-activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure
Ceccarelli, Simona M.,Jaeschke, Georg,Buettelmann, Bernd,Huwyler, Joerg,Kolczewski, Sabine,Peters, Jens-Uwe,Prinssen, Eric,Porter, Richard,Spooren, Will,Vieira, Eric
, p. 1302 - 1306 (2008/09/20)
A novel class of potent and stable mGlu5 receptor antagonists was developed by combining information from a high-throughput screening campaign with the structure of the known anxiolytic fenobam. Representative compounds from this class show favorable phar