1009630-87-8Relevant academic research and scientific papers
Deuterated 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-4-quinazoline derivative and medical composition containing derivative
-
, (2017/02/02)
The invention provides a deuterated 4-[(3-ethynylphenyl)amino] -6,7-benzo-12-crown-4-quinazoline derivative, or crystal forms thereof, and pharmaceutically-acceptable salts, hydrates or solvent compounds thereof. The invention further provides a medical composition containing the compound, and an application of the compound as a disease treating drug. The compound and the medical composition containing the compound, provided by the invention, have long half life, can generate high efficacies and save cost, the treatment effects of patients can be increased, the number of time of medication can be reduced, and the safety potential can be improved.
DEUTERATED ICOTINIB DERIVATIVES
-
Page/Page column 22; 23, (2014/03/22)
The invention relates to novel deuterated Icotinib derivatives and their pharmaceutically acceptable salts, solvates, and prodrugs thereof. This invention also provides compositions comprising any of the deuterated Icotinib derivatives and use of these compounds, or compositions thereof, in preparation of medicaments for treatment of hyperproliferative disorders and diseases.
New deuterated oligo(ethylene glycol) building blocks and their use in the preparation of surface active lipids possessing labeled hydrophilic tethers
Faragher, Robert J.,Schwan, Adrian L.
, p. 1371 - 1378 (2008/04/12)
(Chemical Equation Presented) For the introduction of additional analysis protocols of tethered molecules, a method is presented to prepare functionalized, deuterated oligo(ethylene glycols) from ethylene glycol-d 4. Partial oligomerization of ethylene glycol-d4 and conversion to ditosylates is accompanied by coupling reactions to prepare doubly benzyl protected oligo(ethylene glycols) with two to five repeating units. The tetramer bearing 16 deuteria was elaborated at both ends to eventually prepare 2,3-di-O-phytanyl-sn-glycerol-1-tetraethylene glycol-D,L-α-lipoic acid ester (DPTL), which bears a fully deuterated tetra(ethylene glycol) spacer group. Through linking of functionalized components, an analogue of DPTL possessing an octa(ethylene glycol) spacer group was prepared, both in deuterated and unlabeled form.
