1009640-05-4Relevant academic research and scientific papers
Novel N-chloroheterocyclic antimicrobials
Francavilla, Charles,Turtle, Eric D.,Kim, Bum,O'Mahony, Donogh J.R.,Shiau, Timothy P.,Low, Eddy,Alvarez, Nichole J.,Celeri, Chris E.,D'Lima, Louisa,Friedman, Lisa C.,Ruado, Francis S.,Xu, Ping,Zuck, Meghan E.,Anderson, Mark B.,Najafi, Ramin,Jain, Rakesh K.
scheme or table, p. 3029 - 3033 (2011/06/24)
Antimicrobial compounds with broad-spectrum activity and minimal potential for antibiotic resistance are urgently needed. Toward this end, we prepared and investigated a novel series of N-chloroheterocycles. Of the compounds examined, the N-chloroamine series were found superior over N-chloroamide series in regards to exhibiting high antimicrobial activity, low cytotoxicity, and long-term aqueous stability.
ANTIMICROBIAL OXAZOLIDINONE, HYDANTOIN AND IMIDAZOLIDINONE COMPOSITIONS
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Page/Page column 45-46, (2010/06/11)
The present application relates to N-chlorinated oxazolidinone, hydantoin and imidazolidinone compounds of Formula (I): or pharmaceutically acceptable salts thereof, and associated compositions and methods of use as antimicrobial agents.
HYDANTOIN DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS
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Page/Page column 53-54, (2008/06/13)
This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which is useful for the treatment of diseases or conditions mediated by LpxC.
