100966-82-3Relevant articles and documents
Preparation of α-functionalized alkenylmagnesium reagents via a halide-magnesium exchange
Thibonnet, Jér?me,Anh Vu, Viet,Bérillon, Laurent,Knochel, Paul
, p. 4787 - 4799 (2002)
A general preparation of alkenylmagnesium derivatives bearing an electron-withdrawing function in the α-position (Y=CN, CO2R, CONR2, SO2Ph) has been made possible by using a low temperature (-40 to -30°C) bromine-magnesium exchange with i-PrMgBr in THF. This reaction has also been used to prepare 5-magnesiated-1,3-dioxin-4-one derivatives bearing an alkoxy substituent in β-position to the carbon-magnesium bond.