100969-61-7Relevant academic research and scientific papers
Synthesis, crystal structures of oxovanadium(V) complexes with hydrazone ligands and their catalytic performance for the styrene oxidation
Zhang, Yan,Yang, Ting,Zheng, Bo-Yang,Liu, Ming-Yang,Xing, Na
, p. 123 - 129 (2017)
Four new oxovanadium(V) complexes, [VO(aha)L1] (1), [VO(aha)L2] (2), [VO(aha)L3] (3), and [VO(aha)L4]·EtOH (4) (Haha?=?acetohydroxamic acid, H2L1?=?4-nitrophenyl 2-(2-hydroxybenzylidene)hyd
SOD activity of new copper II complexes with ligands derived from pyridoxal and toxicity in Caenorhabditis elegans
Arantes, Leticia Priscilla,Back, Davi Fernando,Chaves, Otávio Augusto,Iglesias, Bernardo Almeida,Neves, Ademir,Piquini, Paulo Cesar,Siqueira, Josiéli Demétrio,Soares, Félix Antunes,de Pellegrin, Sidnei Flores,dos Santos, Sailer Santos
, (2020)
This work presents the synthesis, characterization of copper(II) complexes (C1-C6) and the potential of these compounds to mimic the catalytic activity of the enzyme superoxide dismutase (SOD). The copper(II)complexes were obtained by reaction between the
Tetrabromomethane as an Organic Catalyst: a Kinetic Study of CBr4-Catalyzed Schiff Condensation
Bolotin, Dmitrii S.,Kukushkin, Vadim Yu.,Tolstoy, Peter M.,Vovk, Mikhail A.,Yunusova, Sevilya N.
supporting information, p. 6763 - 6769 (2020/10/27)
Tetrabromomethane functions as an organic catalyst for non-redox reactions of carbonyl species and, in particular, it enhances the aldehyde–acyl hydrazide condensation to give N-acyl hydrazones. This simple, inexpensive, and commercially available halomet
Combined Alkylating Agents as a Resolution for Highly Selective N-Alkylation of 2-Hydroxybenzaldehyde Acylhydrazones
Cheng, Xin J.,Jin, Long F.,Wu, La M.,Zhang, Hui J.,Zhang, Qiao Y.,Zhao, Xin Y.
supporting information, p. 1334 - 1338 (2019/06/19)
Although 2-hydroxybenzaldehyde acylhydrazones, such as salicylaldehyde acylhydrazones, are intriguing bioactive molecules, few of their N-alkylated derivatives are known, and only methyl analogues have been reported previously. We achieved selective N-alk
Enantioselective N-Heterocyclic Carbene Catalyzed Synthesis of Functionalized Indenes
Zhang, Changhe,Lupton, David W.
supporting information, p. 4456 - 4459 (2017/09/11)
An enantioselective NHC (N-heterocyclic carbene) catalyzed synthesis of indenes from bifunctional α,β-unsaturated acyl fluorides and TMS enol ethers has been discovered. The reaction has broad generality (31 examples) and proceeds with high levels of enantioselectivity (most >92:8 er). Mechanistically the reaction likely occurs via a Michael/β-lactonization/decarboxylation sequence. Derivatization studies and limitations are discussed.
Benzaldehyde Schiff bases regulation to the metabolism, hemolysis, and virulence genes expression in vitro and their structure-microbicidal activity relationship
Xia, Lei,Xia, Yu-Fen,Huang, Li-Rong,Xiao, Xiao,Lou, Hua-Yong,Liu, Tang-Jingjun,Pan, Wei-Dong,Luo, Heng
, p. 83 - 93 (2015/05/20)
There is an urgent need to develop new antibacterial agents because of multidrug resistance by bacteria and fungi. Schiff bases (aldehyde or ketone-like compounds) exhibit intense antibacterial characteristics, and are therefore, promising candidates as antibacterial agents. To investigate the mechanism of action of newly designed benzaldehyde Schiff bases, a series of high-yielding benzaldehyde Schiff bases were synthesized, and their structures were determined by NMR and MS spectra data. The structure-microbicidal activity relationship of derivatives was investigated, and the antibacterial mechanisms were investigated by gene assays for the expression of functional genes in vitro using Escherichia coli, Staphylococcus aureus, and Bacillus subtilis. The active compounds were selective for certain active groups. The polar substitution of the R2 group of the amino acids in the Schiff bases, affected the antibacterial activity against E. coli and S. aureus; specific active group at the R3 or R4 groups of the acylhydrazone Schiff bases could improve their inhibitory activity against these three tested organisms. The antibacterial mechanism of the active benzaldehyde Schiff bases appeared to regulate the expression of metabolism-associated genes in E. coli, hemolysis-associated genes in B. subtilis, and key virulence genes in S. aureus. Some benzaldehyde Schiff bases were bactericidal to all the three strains and appeared to regulate gene expression associated with metabolism, hemolysis, and virulence, in vitro. The newly designed benzaldehyde Schiff bases possessed unique antibacterial activity and might be potentially useful for prophylactic or therapeutic intervention of bacterial infections.
Petasis three-component coupling reactions of hydrazides for the synthesis of oxadiazolones and oxazolidinones
Le Quement, Sebastian T.,Flagstad, Thomas,Mikkelsen, Remi J. T.,Hansen, Mette R.,Givskov, Michael C.,Nielsen, Thomas E.
supporting information; scheme or table, p. 640 - 643 (2012/03/11)
An application of readily available hydrazides in the Petasis 3-component coupling reaction is presented. An investigation of the substrate scope was performed to establish a general, synthetically useful protocol for the formation of hydrazido alcohols, which were selectively converted to oxazolidinone and oxadiazolone ring systems through triphosgene-mediated cyclization reactions.
