1009735-00-5Relevant academic research and scientific papers
Conjugate addition/Ireland-Claisen rearrangements of allyl fumarates: Simple access to terminally differentiated succinates
Bausch, Cory C.,Johnson, Jeffrey S.
, p. 1575 - 1577 (2008/09/17)
(Chemical Equation Presented) The conjugate addition of dialkylzinc reagents to allyl fumarates with subsequent Ireland-Claisen rearrangement has been accomplished yielding substituted unsymmetrical succinic acid derivatives. This one-pot reaction creates two new carbon-carbon bonds at contiguous stereogenic centers. The reaction proceeds for several alkylzinc reagents and substituted allyl fumarates. The products contain distinguishable functional handles for further manipulation.
