1009736-91-7Relevant academic research and scientific papers
Eight-step total synthesis of the cyclopeptide alkaloid mucronine E
Toumi, Mathieu,Couty, Fran?ois,Evano, Gwilherm
, p. 29 - 32 (2008/09/21)
An eight-step total synthesis of the 15-membered ring cyclopeptide alkaloid mucronine E is reported. Key steps include the formation of the highly substituted aromatic core using an asymmetric hydrogenation-Vilsmeier formylation sequence. Central to our approach was a macroamidation protocol using a copper-catalyzed coupling reaction to install the enamide with a concomitant straightforward macrocyclization. This synthesis also allowed for the assignment of both relative and absolute configurations of mucronine E. Georg Thieme Verlag Stuttgart.
