100976-95-2

Upstream product

• 1162198-69-7 (Z)-2-acetoxy-3-(3,4-diacetoxyphenyl)acrylic acid 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 65329-03-5 α-acetylamino-β-(3,4-diacetoxyphenyl)acrylic acid 
• 68307-79-9 2-hydroxy-3-(3,4-dihydroxyphenyl)acrylic acid 
• 23028-17-3 danshensu 
• 108-24-7 acetic anhydride 
• 65329-03-5 2-(acetylamino)-3-[3,4-bis(acetyloxy)phenyl]-(2Z)-2-propenoic acid 
• 68307-79-9 (Z)-3-(3,4-dihydroxyphenyl)-2-hydroxyacrylic acid 

Downstream Products

• 1314941-58-6 S-((R)-3-methoxy-3-oxo-2-aminopropyl) 2-acetoxy-3-(3,4-diacetoxyphenyl)propanethioate 

Relevant academic research and scientific papers

Synthesis and crystal structure of 2-acetoxy-3-(3,4-diacetoxyphenyl) propanoic acid

2-Acetoxy-3-(3,4-diacetoxyphenyl)propanoic acid has been synthesised as a derivative of 2-hydroxy-3-(3,4-dihydroxyphenyl)propanoic acid (danshensu) to improve its chemical stability and liposolubility. It was readily hydrolysed to release the bioactive da

Tanshinol and H2 S/NO Donor binding, preparation method thereof and application in pharmacy (by machine translation)

The invention belongs to the field of chemical pharmacy, and relates to active ingredient tanshinol and H in Chinese herbal medicine Salvia miltiorrhiza. 2 S/NO Donors and its preparation method and use in pharmacy, especially in the preparation of medicines for preventing and treating cardiovascular and cerebrovascular diseases and inflammation related diseases. To the invention, through in-vitro oxidative stress injury and inflammation model experiments, the results show that H is obviously inhibited. 2 O2 In vivo activity experiment results show that the conjugate is capable of remarkably inhibiting the release of inflammatory cytokines induced by LPS (LPS), reducing inflammation-induced mouse peritoneal macrophages, obviously inhibiting the release of inflammatory cytokines induced by LPS, and showing the result that the compound can be used for preparing drugs for preventing and treating cardiovascular and cerebrovascular diseases and inflammatory diseases. (by machine translation)

The synthesis and biological evaluation of novel Danshensu-cysteine analog conjugates as cardiovascular-protective agents

A series of novel amide and thioester conjugates between Danshensu and cysteine derivatives have been designed and synthesized based on the strategy of "medicinal chemical hybridization". Pharmacological evaluation indicated that the amide conjugates 3a/4a/17a and thioester conjugates 6a-d exhibited obvious protective effects on H2O2-induced human umbilical vein endothelial cells (HUVECs). Pretreated with these conjugates could increase glutathione (GSH) activity and decrease malondialdehyde (MDA) level. Further study on mechanism of compound 4a revealed that it was related to its mitochondrial-protective effect and regulation of apoptosis-related proteins expression (Bax, p53, PARP, caspase-3, caspase-9 and Bcl-2). These results indicate that these Danshensu-cysteine analog conjugates possess significant cardiovascular-protective effects and merit further investigation.