1009796-68-2Relevant academic research and scientific papers
Synthesis of 3′,5′-cyclic diguanylic acid (cdiGMP) using 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl as a protecting group for 2′-hydroxy functions of ribonucleosides
Yan, Hongbin,Aguilar, Aime Lopez
, p. 189 - 204 (2008/09/18)
We herein report a convenient synthesis of 3′,5′-cyclic diguanylic acid via the modified H-phosphonate approach. The 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) group was used as protecting group for the 2′-hydroxy functions of ribonucleosides. Complete unblocking of the fully protected 3′,5′-cyclic diguanylic acid gave cdiGMP as a homogeneous compound in an excellent yield. Copyright Taylor & Francis Group, LLC.
