1009827-01-3Relevant academic research and scientific papers
Novel potent pyrimido[4,5-c]quinoline inhibitors of protein kinase CK2: SAR and preliminary assessment of their analgesic and anti-viral properties
Pierre, Fabrice,O'Brien, Sean E.,Haddach, Mustapha,Bourbon, Pauline,Schwaebe, Michael K.,Stefan, Eric,Darjania, Levan,Stansfield, Ryan,Ho, Caroline,Siddiqui-Jain, Adam,Streiner, Nicole,Rice, William G.,Anderes, Kenna,Ryckman, David M.
, p. 1687 - 1691 (2011/05/05)
We describe the discovery of novel potent substituted pyrimido[4,5-c] quinoline ATP-competitive inhibitors of protein kinase CK2. A binding model of the inhibitors with the protein was elaborated on the basis of SAR and revealed various modes of interacti
