100990-00-9Relevant academic research and scientific papers
Design and synthesis of novel breast cancer therapeutic drug candidates based upon the hydrophobic feedback approach of antiestrogens
Ohta, Kiminori,Kaise, Asako,Taguchi, Fumi,Aoto, Sayaka,Ogawa, Takumi,Endo, Yasuyuki
, (2019)
Based upon hydrophobic feedback approaches, we designed and synthesized novel sulfur-containing ERα modulators (4 and 5) as breast cancer therapeutic drug candidates. The tetrahydrothiepine derivative 5a showed the highest binding affinity toward ERα beca
GENERAL SYNTHESIS OF 2,5-DIHYDROTHIOPHENES (3-THIOLENES) FROM DIKETO SULFIDES
Nakayama, Juzo,Machida, Haruki,Hoshino, Masamatsu
, p. 1981 - 1982 (2007/10/02)
The intramolecular reductive coupling reaction of easily accesible diketo sulfides by a low-valent titanium reagent (prepared from titanium(IV) chloride and zinc powder) provides an efficient general synthesis of 2,5-dihydrothiophenes.
