101-56-4

Basic information

• Product Name: Benzenediazonium, 4-(phenylamino)-, chloride
• Synonyms: P-PHENYLAMINOBENZENEDIAZONIUMCHLORIDE;4-(phenylamino)-benzenediazoniuchloride;4-anilinobenzenediazonium chloride;4-Diazoniodiphenylamine·chloride;Diphenylamine-4-diazonium chloride;4-phenylazanylbenzenediazonium chloride
• CAS NO: 101-56-4
• Molecular Formula: C₁₂H₁₀N₃*Cl
• Molecular Weight: 231.68
• EINECS: 202-954-5
• Mol File: 101-56-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: Benzenediazonium, 4-(phenylamino)-, chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenediazonium, 4-(phenylamino)-, chloride(101-56-4)
• EPA Substance Registry System: Benzenediazonium, 4-(phenylamino)-, chloride(101-56-4)

Safety Data

• Hazardous Substances Data: 101-56-4(Hazardous Substances Data)

Usage

General Description

Benzenediazonium, 4-(phenylamino)-, chloride is a chemical compound with the molecular formula C12H10ClN3. This compound is part of the diazonium salt class and consists of a benzene ring with a diazonium group (-N2+) attached to it at the 4-position, as well as a phenylamino group (-C6H5NH2) linked to the diazonium nitrogen atom. It is commonly used in organic synthesis as a versatile intermediate for the preparation of various organic compounds, including dyes, pigments, and pharmaceuticals. The diazonium group can undergo a variety of reactions, such as diazo coupling reactions, to form new organic compounds. Handling diazonium salts requires caution due to their potential reactivity and instability, particularly in the presence of heat and light.

InChI:InChI=1/C12H10N3.ClH/c13-15-12-8-6-11(7-9-12)14-10-4-2-1-3-5-10;/h1-9,14H;1H/q+1;/p-1

Upstream product

• 101-54-2 N-phenylphenylene-1,4-diamine 

Downstream Products

• 121501-61-9 7-chloro-2-(p-anilinophenyl)-2H-benzotriazolyl-5-amine 

Relevant articles and documents

APPLICATION OF FLUORESCENT TRIAZOLES TO ANALYTICAL CHEMISTRY. IV. DEVELOPMENT OF A NEW FLUORESCENT PROBE FOR BASIC DRUG-α1-ACID GLYCOPROTEIN BINDING MEASUREMENT

A fluorescent probe applicable to protein binding measurement was developed.Several 2-phenylbenzotriazolyl-5-amine derivatives having an amino group on the 2-phenyl ring were synthesized.Their fluorescence characteristics and the binding affinity to α1-acid glycoprotein (α1-AGP) were investigated.They were practically non-fluorescent in aqueous solution, but were highly fluorescent in the presence of α1-AGP.This fluorescence was due to the binding of these compounds to α1-AGP.Of all the compounds synthesized, 7-chloro-2-(p-diethylaminophenyl)-2H-benzotriazolyl-5-amine (CDBA) bound to α1-AGP most strongly and was used as a fluorescent probe.The binding parameters of CDBA were estimated by the fluormetric titration method to be log K = 6.18 and n = 0.40.The fluorescence of CDBA in the α1-AGP solution was markedly quenched in the presence of basic drugs, indicating that these drugs competitively displace CDBA bound to α1-AGP.The binding constants of the basic drugs were calculated, based on the decrease of fluorescence intensity in the presence of the drug.The binding strength of the drugs tested ranged from 4.7 to 6.8 as log K value.Keywords: fluorescent probe; fluorescence characteristics; protein binding; binding parameter; α-acid glycoprotein; competition; basic drug; benzotriazole: 7-chloro-2-(p-diethylaminophenyl)-2H-benzotriazolyl-5-amine